Butyric acid, 4-(p-chloro-N-2,6-xylylbenzamido)- → HCID 22814601, compound

HRID 1413604Notes

Reaction equation

HRID 1413604 reaction equation
[Cl:1][C:2]1[CH:24]=[CH:23][C:5]([C:6]([N:8]([CH2:17][CH2:18][CH2:19][C:20](O)=[O:21])[C:9]2[C:14]([CH3:15])=[CH:13][CH:12]=[CH:11][C:10]=2[CH3:16])=[O:7])=[CH:4][CH:3]=1.[NH2:25][C@H:26]([C:34]([O:36][CH2:37][CH3:38])=[O:35])[CH2:27][C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1>>[Cl:1][C:2]1[CH:24]=[CH:23][C:5]([C:6]([N:8]([CH2:17][CH2:18][CH2:19][C:20]([NH:25][C@H:26]([C:34]([O:36][CH2:37][CH3:38])=[O:35])[CH2:27][C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)=[O:21])[C:9]2[C:10]([CH3:16])=[CH:11][CH:12]=[CH:13][C:14]=2[CH3:15])=[O:7])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 35383Butyric acid, 4-(p-chloro-N-2,6-xylylbenzamido)-HCID 76506Phenylalanine ethyl ester

Product 1

HCID 22814601HCID 22814601, compound

Procedure

Analogously to Example 1, by using equivalent quantities, reacting N-(p-chlorobenzoyl)-4-(2,6-dimethylanilino)butyric acid and ethyl L-phenylalaninate and suitable processing produces ethyl N-[N-(p-chlorobenzoyl)-4-(2,6-dimethylanilino)butyryl]-L-phenylalaninate (oil), saponification of which and processing of the reaction product yields N-(p-chlorobenzoyl)-4-(2,6-dimethylanilino)butyryl-L-phenylalanine (M.P. 153° to 155°).

Sources & evidence

ORD record
ord-b0778b1053a54d3bb8fa6fa5d6e51f81
Source dataset
uspto-grants-1981_02
Patent number
US04250183

Reaction notes

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