Glycine ethyl ester → HCID 20292084, compound

HRID 1413605Notes

Reaction equation

HRID 1413605 reaction equation
[Cl:1][C:2]1[CH:23]=[CH:22][C:5]([C:6]([N:8]([CH2:17][CH2:18][C:19]([OH:21])=O)[C:9]2[CH:16]=[CH:15][C:12]([O:13][CH3:14])=[CH:11][CH:10]=2)=[O:7])=[CH:4][CH:3]=1.[NH2:24][CH2:25][C:26]([O:28][CH2:29][CH3:30])=[O:27]>>[Cl:1][C:2]1[CH:23]=[CH:22][C:5]([C:6]([N:8]([CH2:17][CH2:18][C:19]([NH:24][CH2:25][C:26]([O:28][CH2:29][CH3:30])=[O:27])=[O:21])[C:9]2[CH:10]=[CH:11][C:12]([O:13][CH3:14])=[CH:15][CH:16]=2)=[O:7])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 12176Glycine ethyl esterHCID 20292098HCID 20292098, compound

Product 1

HCID 20292084HCID 20292084, compound

Procedure

Analogously to Example 1, by using equivalent quantities, reacting N-(p-chlorobenzoyl)-3-(p-anisidino)propionic acid and ethyl glycinate and suitable processing produces ethyl N-[N-(p-chlorobenzoyl)-3-(p-anisidino)propionyl]glycinate (M.P. 87° to 89°), saponification of which and processing of the reaction product yields N-[N-(p-chlorobenzoyl)-3-(p-anisidino)propionyl]glycine (M.P. 185° to 187°).

Sources & evidence

ORD record
ord-501d46dbb72b4a34a21e4072e6f6962b
Source dataset
uspto-grants-1981_02
Patent number
US04250183

Reaction notes

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