HuagongsheHuagongshe Chemistry Print Report · For research reference only
L-Proline, ethyl ester → ethyl N-[N-(p-chlorobenzoyl)-2-(2,6-dimethylanilino)acetyl]-L-prolinate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | L-Proline, ethyl ester | HCID 79888 | — |
| Reactant | N-(p-chlorobenzoyl)-2-(2,6-dimethylanilino)acetic acid | HCID 20292207 | — |
| Product | ethyl N-[N-(p-chlorobenzoyl)-2-(2,6-dimethylanilino)acetyl]-L-prolinate | HCID 22814600 | — |
Reaction Steps
Analogously to Example 1, by using equivalent quantities, reacting N-(p-chlorobenzoyl)-2-(2,6-dimethylanilino)acetic acid and ethyl L-prolinate and suitable processing produces ethyl N-[N-(p-chlorobenzoyl)-2-(2,6-dimethylanilino)acetyl]-L-prolinate (oil), saponification of which and processing of the reaction product yields N-[N-(p-chlorobenzoyl)-2-(2,6-dimethylanilino)acetyl]-L-proline (M.P. 199°).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04250183 |
| Source dataset | uspto-grants-1981_02 |
| ORD ID | ord-d2801741b8154efd97664cb4afa4d623 |
| Source note | uspto-grants-1981_02 |