Potassium Hydroxide → HCID 22814618, compound

HRID 1413613Notes

Reaction equation

HRID 1413613 reaction equation
[F:1][C:2]1[CH:24]=[CH:23][C:5]([C:6]([N:8]([C:15]([CH3:22])([CH3:21])[CH2:16][C:17]([CH3:20])([CH3:19])[CH3:18])[CH2:9][CH2:10][CH2:11][C:12](O)=[O:13])=[O:7])=[CH:4][CH:3]=1.[NH:25]1[CH2:34][CH2:33][CH2:32][C@H:26]1[C:27]([O:29]CC)=[O:28].[OH-].[K+]>C(O)C>[F:1][C:2]1[CH:24]=[CH:23][C:5]([C:6]([N:8]([C:15]([CH3:22])([CH3:21])[CH2:16][C:17]([CH3:18])([CH3:19])[CH3:20])[CH2:9][CH2:10][CH2:11][C:12]([N:25]2[CH2:34][CH2:33][CH2:32][C@H:26]2[C:27]([OH:29])=[O:28])=[O:13])=[O:7])=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 14797Potassium HydroxideHCID 79888L-Proline, ethyl esterHCID 20292234HCID 20292234, compound

Product 1

HCID 22814618HCID 22814618, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Analogously to Example 1, by using equivalent quantities, reacting N-(p-fluorobenzoyl)-4-[(1,1,3,3-tetramethylbutyl)amino]butyric acid and ethyl L-prolinate and suitable processing, dissolving the evaporation residue in ethanol, adding an ethanolic solution of potassium hydroxide, stirring for 12 hours at room temperature and further processing yields N-[N-(p-fluorobenzoyl)-4-(1,1,3,3-tetramethylbutylamino)butyryl]-L-proline.

Sources & evidence

ORD record
ord-3a1b838693a4444faa90546f5aa057bb
Source dataset
uspto-grants-1981_02
Patent number
US04250183

Reaction notes

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