Potassium Hydroxide → HCID 20292081, compound

HRID 1413615Notes

Reaction equation

HRID 1413615 reaction equation
[Cl:1][C:2]1[CH:21]=[CH:20][C:5]([C:6]([N:8]([C:15]([CH3:19])([CH3:18])[CH2:16][CH3:17])[CH2:9][CH2:10][CH2:11][C:12]([OH:14])=O)=[O:7])=[CH:4][CH:3]=1.[CH2:22]([C:24]1[CH:38]=[CH:37][CH:36]=[C:35]([CH2:39][CH3:40])[C:25]=1[NH:26][CH2:27][CH2:28][CH2:29][C:30]([O:32]CC)=[O:31])[CH3:23].[OH-].[K+]>C(O)C>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]([N:8]([C:15]([CH3:19])([CH3:18])[CH2:16][CH3:17])[CH2:9][CH2:10][CH2:11][C:12]([N:26]([CH2:27][CH2:28][CH2:29][C:30]([OH:32])=[O:31])[C:25]2[C:35]([CH2:39][CH3:40])=[CH:36][CH:37]=[CH:38][C:24]=2[CH2:22][CH3:23])=[O:14])=[O:7])=[CH:20][CH:21]=1

Participants

5

Reactant 3

HCID 14797Potassium HydroxideHCID 20292102HCID 20292102, compoundHCID 20292162HCID 20292162, compound

Product 1

HCID 20292081HCID 20292081, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Analogously to Example 1, by using equivalent quantities, reacting N-(p-chlorobenzoyl)-4-[(1,1-dimethylpropyl)amino]butyric acid and ethyl γ-(2,6-diethylanilino)butyrate and suitable processing, dissolving the evaporation residue in ethanol, adding an ethanolic solution of potassium hydroxide, stirring for 12 hours at room temperature and further processing yields N-[N-(p-chlorobenzoyl)-4-(1,1-dimethylpropylamino)butyryl]-4-(2,6-diethylanilino)butyric acid.

Sources & evidence

ORD record
ord-ed5967bb06a44d7794795ca1472940a8
Source dataset
uspto-grants-1981_02
Patent number
US04250183

Reaction notes

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