Potassium Hydroxide → HCID 20292233, compound

HRID 1413616Notes

Reaction equation

HRID 1413616 reaction equation
[Cl:1][C:2]1[CH:21]=[C:20]([Cl:22])[CH:19]=[CH:18][C:3]=1[C:4]([N:6]([C:13]([CH3:17])([CH3:16])[CH2:14][CH3:15])[CH2:7][CH2:8][CH2:9][C:10]([OH:12])=O)=[O:5].[CH3:23][O:24][C:25]1[CH:30]=[CH:29][C:28]([NH:31][CH2:32][CH2:33][CH2:34][C:35]([O:37]C)=[O:36])=[CH:27][CH:26]=1.[OH-].[K+]>C(O)C>[Cl:1][C:2]1[CH:21]=[C:20]([Cl:22])[CH:19]=[CH:18][C:3]=1[C:4]([N:6]([C:13]([CH3:17])([CH3:16])[CH2:14][CH3:15])[CH2:7][CH2:8][CH2:9][C:10]([N:31]([CH2:32][CH2:33][CH2:34][C:35]([OH:37])=[O:36])[C:28]1[CH:27]=[CH:26][C:25]([O:24][CH3:23])=[CH:30][CH:29]=1)=[O:12])=[O:5]

Participants

5

Reactant 3

HCID 14797Potassium HydroxideHCID 12467904HCID 12467904, compoundHCID 20292093HCID 20292093, compound

Product 1

HCID 20292233HCID 20292233, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Analogously to Example 1, by using equivalent quantities, reacting N-(2,4-dichlorobenzoyl)-4-[(1,1dimethylpropyl)amino]butyric acid and methyl γ-(p-anisidino)butyrate and suitable processing, dissolving the evaporation residue in ethanol, adding an ethanolic solution of potassium hydroxide, stirring for 12 hours at room temperature and further processing yields N-[N-(2,4-dichlorobenzoyl)-4-(1,1-dimethylpropylamino)butyryl]-4-(p-anisidino)butyric acid.

Sources & evidence

ORD record
ord-3ea825f080274e02aeab3aa3b8eec9c8
Source dataset
uspto-grants-1981_02
Patent number
US04250183

Reaction notes

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