Potassium Hydroxide → HCID 86737492, compound

HRID 1413617Notes

Reaction equation

HRID 1413617 reaction equation
[CH2:1]([C:3]([NH:8][CH2:9][CH2:10][CH2:11][C:12]([O:14]CC)=[O:13])([CH2:6][CH3:7])[C:4]#[CH:5])[CH3:2].[OH-].[K+]>C(O)C>[CH2:4]([C:3]([NH:8][CH2:9][CH2:10][CH2:11][C:12]([OH:14])=[O:13])([CH2:6][CH3:7])[C:1]#[CH:2])[CH3:5]

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 20292196HCID 20292196, compound

Product 1

HCID 86737492HCID 86737492, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Analogously to Example 1, by using equivalent quantities, reacting N-(p-chlorobenzoyl-4-[(1-ethynylcyclohexyl-1)-amino]butyric acid and ethyl 4-[(3-ethyl-1-pentyn3-yl)amino]butyrate and suitable processing, dissolving the evaporation residue in ethanol, adding an ethanolic solution of potassium hydroxide, stirring for 12 hours at room temperature and further processing yields N-[p-chlorobenzoyl)-4-(1-ethynylcyclohexyl-1-amino)butyryl]-4-(3-ethyl-1-pentyn-3-ylamino)butyric acid.

Sources & evidence

ORD record
ord-6804fa10ad6d45deb7da4fe263bf0eef
Source dataset
uspto-grants-1981_02
Patent number
US04250183

Reaction notes

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