Potassium Hydroxide → HCID 20292247, compound

HRID 1413618Notes

Reaction equation

HRID 1413618 reaction equation
[Cl:1][C:2]1[CH:26]=[CH:25][C:5]([C:6]([N:8]([C:15]23[CH2:24][CH:19]4[CH2:20][CH:21]([CH2:23][CH:17]([CH2:18]4)[CH2:16]2)[CH2:22]3)[CH2:9][CH2:10][CH2:11][C:12](O)=[O:13])=[O:7])=[CH:4][CH:3]=1.[NH2:27][CH2:28][CH2:29][C:30]([O:32]CC)=[O:31].[OH-].[K+]>C(O)C>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]([N:8]([C:15]23[CH2:24][CH:19]4[CH2:20][CH:21]([CH2:23][CH:17]([CH2:18]4)[CH2:16]2)[CH2:22]3)[CH2:9][CH2:10][CH2:11][C:12]([NH:27][CH2:28][CH2:29][C:30]([OH:32])=[O:31])=[O:13])=[O:7])=[CH:25][CH:26]=1

Participants

5

Reactant 3

HCID 14797Potassium HydroxideHCID 419889Ethyl 3-aminopropanoateHCID 20292129HCID 20292129, compound

Product 1

HCID 20292247HCID 20292247, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Analogously to Example 1, by using equivalent quantities, reacting N-(p-chlorobenzoyl)-4-(1-adamantylamino)butyric acid and ethyl 3-aminopropionate and suitable processing, dissolving the evaporation residue in ethanol, adding an ethanolic solution of potassium hydroxide, stirring for 12 hours at room temperature and further processing yields N-[N-(p-chlorobenzoyl)-4-(1-adamantylamino)butyryl]-3-aminopropionic acid.

Sources & evidence

ORD record
ord-7146262b988a4bd6b59b048e06309ef0
Source dataset
uspto-grants-1981_02
Patent number
US04250183

Reaction notes

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