Potassium Hydroxide → HCID 20292120, compound

HRID 1413619Notes

Reaction equation

HRID 1413619 reaction equation
[Cl:1][C:2]1[CH:29]=[CH:28][C:5]([C:6]([N:8]([CH:15]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[CH2:9][CH2:10][CH2:11][C:12](O)=[O:13])=O)=[CH:4][CH:3]=1.[CH:30]([NH:43][CH2:44][CH2:45][CH2:46][CH2:47][C:48]([O:50]CC)=[O:49])([C:37]1[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=1)[C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1.[OH-:53].[K+]>C(O)C>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]([N:8]([CH:15]([C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=2)[C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=2)[CH2:9][CH2:10][CH2:11][C:12]([N:43]([CH:30]([C:37]2[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=2)[C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)[CH2:44][CH2:45][CH2:46][CH2:47][C:48]([OH:50])=[O:49])=[O:13])=[O:53])=[CH:28][CH:29]=1

Participants

5

Reactant 3

HCID 14797Potassium HydroxideHCID 20292147HCID 20292147, compoundHCID 20292267HCID 20292267, compound

Product 1

HCID 20292120HCID 20292120, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Analogously to Example 1, by using equivalent quantities, reacting N-(p-chlorobenzoyl)-4-benzhydrylaminobutyric acid and ethyl 5-benzhydrylaminovalerate and suitable processing, dissolving the evaporation residue in ethanol, adding an ethanolic solution of potassium hydroxide, stirring for 12 hours at room temperature and further processing yields N-[N-(p-chlorobenzoyl)-4-benzhydrylaminobutyryl]-5-benzhydrylaminovaleric acid.

Sources & evidence

ORD record
ord-779e9e8152014987b545661fc0357ded
Source dataset
uspto-grants-1981_02
Patent number
US04250183

Reaction notes

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