Potassium Hydroxide → HCID 20292197, compound

HRID 1413620Notes

Reaction equation

HRID 1413620 reaction equation
[Cl:1][C:2]1[CH:24]=[CH:23][C:5]([C:6]([N:8]([CH:15]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH3:16])[CH2:9][CH2:10][CH2:11][C:12](O)=[O:13])=[O:7])=[CH:4][CH:3]=1.[CH2:25]([NH:32][CH2:33][CH2:34][CH2:35][C:36]([O:38]CC)=[O:37])[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1.[OH-].[K+]>C(O)C>[Cl:1][C:2]1[CH:24]=[CH:23][C:5]([C:6]([N:8]([CH:15]([C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=2)[CH3:16])[CH2:9][CH2:10][CH2:11][C:12]([N:32]([CH2:25][C:26]2[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=2)[CH2:33][CH2:34][CH2:35][C:36]([OH:38])=[O:37])=[O:13])=[O:7])=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 14797Potassium HydroxideHCID 12220642HCID 12220642, compoundHCID 20292203HCID 20292203, compound

Product 1

HCID 20292197HCID 20292197, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Analogously to Example 1, by using equivalent quantities, reacting N-(p-chlorobenzoyl)-4-(1-phenylethylamino)butyric acid and ethyl 4-benzylaminobutyrate and suitable processing, dissolving the evaporation residue in ethanol, adding an ethanolic solution of potassium hydroxide, stirring for 12 hours at room temperature and further processing yields N-[N-(p-chorobenzoyl)-4-(1-phenylethylamino)butyryl]-4-benzylaminobutyric acid.

Sources & evidence

ORD record
ord-9ee74a0ad0cf4b4784ae4ff0cb59386c
Source dataset
uspto-grants-1981_02
Patent number
US04250183

Reaction notes

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