Potassium Hydroxide → HCID 20292268, compound

HRID 1413621Notes

Reaction equation

HRID 1413621 reaction equation
[Cl:1][C:2]1[CH:26]=[CH:25][C:5]([C:6]([N:8]([CH:17]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH3:18])[CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][C:14](O)=[O:15])=[O:7])=[CH:4][CH:3]=1.[CH2:27]([NH:34][CH2:35][CH2:36][CH2:37][C:38]([O:40]CC)=[O:39])[C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1.[OH-].[K+]>C(O)C>[Cl:1][C:2]1[CH:26]=[CH:25][C:5]([C:6]([N:8]([CH:17]([C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=2)[CH3:18])[CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][C:14]([N:34]([CH2:27][C:28]2[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=2)[CH2:35][CH2:36][CH2:37][C:38]([OH:40])=[O:39])=[O:15])=[O:7])=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 14797Potassium HydroxideHCID 12220642HCID 12220642, compoundHCID 20292132HCID 20292132, compound

Product 1

HCID 20292268HCID 20292268, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Analogously to Example 1, by using equivalent quantities, reacting N-(p-chlorobenzoyl)-6-(1-phenylethylamino)caproic acid and ethyl 4-benzylaminobutyrate and suitable processing, dissolving the evaporation residue in ethanol, adding an ethanolic solution of potassium hydroxide, stirring for 12 hours at room temperature and further processing yields N-[N-(p-chlorobenzoyl)-6-(1-phenylethylamino)hexanoyl]-4-benzylaminobutyric acid.

Sources & evidence

ORD record
ord-239d37c50c994bb6901dcf15603cc745
Source dataset
uspto-grants-1981_02
Patent number
US04250183

Reaction notes

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