Potassium Hydroxide → HCID 20292187, compound

HRID 1413622Notes

Reaction equation

HRID 1413622 reaction equation
[Cl:1][C:2]1[CH:28]=[CH:27][C:5]([C:6]([N:8]([CH2:15][CH2:16][C:17]2[CH:26]=[CH:25][C:22]([O:23][CH3:24])=[C:19]([O:20][CH3:21])[CH:18]=2)[CH2:9][CH2:10][CH2:11][C:12](O)=[O:13])=[O:7])=[CH:4][CH:3]=1.[NH2:29][CH2:30][CH2:31][CH2:32][C:33]([O:35]C)=[O:34].[OH-].[K+]>C(O)C>[Cl:1][C:2]1[CH:28]=[CH:27][C:5]([C:6]([N:8]([CH2:15][CH2:16][C:17]2[CH:26]=[CH:25][C:22]([O:23][CH3:24])=[C:19]([O:20][CH3:21])[CH:18]=2)[CH2:9][CH2:10][CH2:11][C:12]([NH:29][CH2:30][CH2:31][CH2:32][C:33]([OH:35])=[O:34])=[O:13])=[O:7])=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 14797Potassium HydroxideHCID 18614Methyl 4-aminobutanoateHCID 20292258HCID 20292258, compound

Product 1

HCID 20292187HCID 20292187, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Analogously to Example 1, by using equivalent quantities, reacting N-(p-chlorobenzoyl)-4-homoveratrylaminobutyric acid and methyl 4-aminobutyrate and suitable processing, dissolving the evaporation residue in ethanol, adding an ethanolic solution of potassium hydroxide, stirring for 12 hours at room temperature and further processing yields N-[N-(p-chlorobenzoyl)-4-(homoveratrylamino)butyryl]-4-aminobutyric acid.

Sources & evidence

ORD record
ord-5cbe0f457a94482ab6bf6a351dfb724e
Source dataset
uspto-grants-1981_02
Patent number
US04250183

Reaction notes

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