Potassium Hydroxide → HCID 20292155, compound

HRID 1413623Notes

Reaction equation

HRID 1413623 reaction equation
[Cl:1][C:2]1[CH:30]=[CH:29][C:5]([C:6]([N:8]([CH:15]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH2:9][CH2:10][CH2:11][C:12](O)=[O:13])=[O:7])=[CH:4][CH:3]=1.[NH2:31][CH2:32][CH2:33][C:34]([O:36]CC)=[O:35].[OH-].[K+]>C(O)C>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]([N:8]([CH:15]([C:23]2[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=2)[CH2:16][C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=2)[CH2:9][CH2:10][CH2:11][C:12]([NH:31][CH2:32][CH2:33][C:34]([OH:36])=[O:35])=[O:13])=[O:7])=[CH:29][CH:30]=1

Participants

5

Reactant 3

HCID 14797Potassium HydroxideHCID 419889Ethyl 3-aminopropanoateHCID 20292064HCID 20292064, compound

Product 1

HCID 20292155HCID 20292155, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Analogously to Example 1, by using equivalent quantities, reacting N-(p-chlorobenzoyl)-4-[(1,2-diphenylethyl)amino]butyric acid and ethyl 3-aminopropionate and suitable processing, dissolving the evaporation residue in ethanol, adding an ethanolic solution of potassium hydroxide, stirring for 12 hours at room temperature and further processing yields N-[N-(p-chlorobenzoyl)-4-(1,2-diphenylethylamino)butyryl]-3-aminopropionic acid.

Sources & evidence

ORD record
ord-881ce5dceb1b49f581f1e46518ac9c8f
Source dataset
uspto-grants-1981_02
Patent number
US04250183

Reaction notes

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