Potassium Hydroxide → HCID 22814613, compound

HRID 1413624Notes

Reaction equation

HRID 1413624 reaction equation
[Cl:1][C:2]1[CH:16]=[CH:15][C:5]([C:6]([NH:8][CH2:9][CH2:10][CH2:11][C:12]([OH:14])=O)=[O:7])=[CH:4][CH:3]=1.[NH:17]1[CH2:26][CH2:25][CH2:24][C@H:18]1[C:19]([O:21]CC)=[O:20].[OH-].[K+]>C(O)C>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]([NH:8][CH2:9][CH2:10][CH2:11][C:12]([N:17]2[CH2:26][CH2:25][CH2:24][C@H:18]2[C:19]([OH:21])=[O:20])=[O:14])=[O:7])=[CH:15][CH:16]=1

Participants

5

Reactant 3

HCID 14797Potassium HydroxideHCID 79888L-Proline, ethyl esterHCID 22325744-(4-Chloro-benzoylamino)-butyric acid

Product 1

HCID 22814613HCID 22814613, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Analogously to Example 1, by using equivalent quantities, reacting N-(p-chlorobenzoyl)-4-aminobutyric acid and ethyl L-prolinate and suitable processing, dissolving the evaporation residue in ethanol, adding an ethanolic solution of potassium hydroxide, stirring for 12 hours at room temperature and further processing yields N-[N-(p-chlorobenzoyl)-4-aminobutyryl]-L-proline.

Sources & evidence

ORD record
ord-81ff344747fc43f4b12d2cdb7253bc03
Source dataset
uspto-grants-1981_02
Patent number
US04250183

Reaction notes

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