Potassium Hydroxide → HCID 20292106, compound

HRID 1413625Notes

Reaction equation

HRID 1413625 reaction equation
[F:1][C:2]([F:27])([F:26])[C:3]1[CH:4]=[C:5]([CH:23]=[CH:24][CH:25]=1)[C:6]([N:8]([C:15]([CH3:22])([CH3:21])[CH2:16][C:17]([CH3:20])([CH3:19])[CH3:18])[CH2:9][CH2:10][CH2:11][C:12](O)=[O:13])=[O:7].[NH2:28][CH2:29][CH2:30][C:31]([O:33]CC)=[O:32].[OH-].[K+]>C(O)C>[F:1][C:2]([F:26])([F:27])[C:3]1[CH:4]=[C:5]([CH:23]=[CH:24][CH:25]=1)[C:6]([N:8]([C:15]([CH3:21])([CH3:22])[CH2:16][C:17]([CH3:20])([CH3:18])[CH3:19])[CH2:9][CH2:10][CH2:11][C:12]([NH:28][CH2:29][CH2:30][C:31]([OH:33])=[O:32])=[O:13])=[O:7]

Participants

5

Reactant 3

HCID 14797Potassium HydroxideHCID 419889Ethyl 3-aminopropanoateHCID 20292237HCID 20292237, compound

Product 1

HCID 20292106HCID 20292106, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Analogously to Example 1, by using equivalent quantities, reacting N-(m-trifluoromethylbenzoyl)-4-[(1,1,3,3-tetramethylbutyl)amino]butyric acid and ethyl 3-aminopropionate and suitable processing, dissolving the evaporation residue in ethanol, adding an ethanolic solution of potassium hydroxide, stirring for 12 hours at room temperature and further processing yields N-[N-(m-trifluoromethylbenzoyl)-4-(1,1,3,3-tetramethylbutylamino)butyryl]-3-aminopropionic acid.

Sources & evidence

ORD record
ord-1c73258be3d84b85a50d796aced346b3
Source dataset
uspto-grants-1981_02
Patent number
US04250183

Reaction notes

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