Ethanol → HCID 20292072, compound

HRID 1413626Notes

Reaction equation

HRID 1413626 reaction equation
[C:1]([N:5]([CH:12]([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[CH2:6][CH2:7]CC(O)=O)(=O)[CH2:2][CH3:3].[CH:25]([NH:38][CH2:39][CH2:40][CH2:41][CH2:42][C:43]([O:45]CC)=[O:44])([C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1)[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1.[OH-:48].[K+].[CH2:50]([OH:52])[CH3:51]>>[C:1]([N:5]([CH:12]([C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1)[C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1)[CH2:6][CH2:7][CH2:51][C:50]([N:38]([CH:25]([C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)[C:32]1[CH:33]=[CH:34][CH:35]=[CH:36][CH:37]=1)[CH2:39][CH2:40][CH2:41][CH2:42][C:43]([OH:45])=[O:44])=[O:52])(=[O:48])[CH2:2][CH3:3]

Participants

5

Reactant 4

HCID 702EthanolHCID 14797Potassium HydroxideHCID 20292147HCID 20292147, compoundHCID 20292255HCID 20292255, compound

Product 1

HCID 20292072HCID 20292072, compound

Procedure

Analogously to Example 1, by using equivalent quantities, reacting N-propionyl-4-benzhydrylaminobutyric acid and ethyl 5-benzhydrylaminovalerate and suitable processing, dissolving the evaporation residue in ethanol, adding an ethanolic solution of potassium hydroxide, stirring for 12 hours at room temperature and further processing yields N-[N-propionyl-4-benzhydrylaminobutyryl]-5-benzhydrylaminovaleric acid.

Sources & evidence

ORD record
ord-0a2d6209c96e4363b958a8dc758ac706
Source dataset
uspto-grants-1981_02
Patent number
US04250183

Reaction notes

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