Ethanol → HCID 20292114, compound

HRID 1413629Notes

Reaction equation

HRID 1413629 reaction equation
[C:1]([N:4]([CH:12]([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[CH2:5][CH2:6][CH2:7][CH2:8][C:9]([OH:11])=[O:10])(=[O:3])[CH3:2].[CH:25]([NH:38][CH2:39][CH2:40][CH2:41]CC(OCC)=O)([C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1)[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1.[OH-].[K+].[CH2:50]([OH:52])[CH3:51]>>[C:50]([N:38]([CH:25]([C:26]1[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=1)[C:32]1[CH:33]=[CH:34][CH:35]=[CH:36][CH:37]=1)[CH2:39][CH2:40][CH2:41][CH2:2][C:1]([N:4]([CH:12]([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[CH2:5][CH2:6][CH2:7][CH2:8][C:9]([OH:11])=[O:10])=[O:3])(=[O:52])[CH3:51]

Participants

5

Reactant 4

HCID 702EthanolHCID 14797Potassium HydroxideHCID 20292147HCID 20292147, compoundHCID 20292163HCID 20292163, compound

Product 1

HCID 20292114HCID 20292114, compound

Procedure

Analogously to Example 1, by using equivalent quantities, reacting N-acetyl-5-benzhydrylaminovaleric acid and ethyl 5-benzhydrylaminovalerate and suitable processing, dissolving the evaporation residue in ethanol, adding an ethanolic solution of potassium hydroxide, stirring for 12 hours at room temperature and further processing yields N-(N-acetyl-5-benzhydrylaminopentanoyl)-5-benzhydrylaminovaleric acid.

Sources & evidence

ORD record
ord-9ef120ead5a44624a2936166b6a4b2fb
Source dataset
uspto-grants-1981_02
Patent number
US04250183

Reaction notes

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