Potassium Hydroxide → HCID 20292228, compound

HRID 1413630Notes

Reaction equation

HRID 1413630 reaction equation
[C:1]([N:6]([CH:14]([C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)[CH2:7][CH2:8][CH2:9][CH2:10][C:11](O)=[O:12])(=[O:5])/[CH:2]=[CH:3]/[CH3:4].[NH2:27][CH2:28][CH2:29][C:30]([O:32]CC)=[O:31].[OH-].[K+]>C(O)C>[C:1]([N:6]([CH:14]([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)[CH2:7][CH2:8][CH2:9][CH2:10][C:11]([NH:27][CH2:28][CH2:29][C:30]([OH:32])=[O:31])=[O:12])(=[O:5])/[CH:2]=[CH:3]/[CH3:4]

Participants

5

Reactant 3

HCID 14797Potassium HydroxideHCID 419889Ethyl 3-aminopropanoateHCID 20292179HCID 20292179, compound

Product 1

HCID 20292228HCID 20292228, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Analogously to Example 1, by using equivalent quantities, reacting N-crotonoyl-5-benzhydrylaminovaleric acid and ethyl 3-aminopropionate and suitable processing, dissolving the evaporation residue in ethanol, adding an ethanolic solution of potassium hydroxide, stirring for 12 hours at room temperature and further processing yields N-(N-crotonoyl-5-benzhydrylaminopentanoyl)-3-aminopropionic acid.

Sources & evidence

ORD record
ord-db9008672a4e4703bb4c383987e37705
Source dataset
uspto-grants-1981_02
Patent number
US04250183

Reaction notes

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