Potassium Hydroxide → HCID 20292224, compound

HRID 1413632Notes

Reaction equation

HRID 1413632 reaction equation
[Cl:1][C:2]1[CH:21]=[CH:20][C:5]([C:6]([N:8]([CH2:16][CH2:17][CH2:18][CH3:19])[CH2:9][CH2:10][CH2:11][CH2:12][C:13]([OH:15])=O)=[O:7])=[CH:4][CH:3]=1.[CH:22]([NH:35][CH2:36][CH2:37][CH2:38][CH2:39][C:40]([O:42]CC)=[O:41])([C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1)[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1.[OH-].[K+]>C(O)C>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]([N:8]([CH2:16][CH2:17][CH2:18][CH3:19])[CH2:9][CH2:10][CH2:11][CH2:12][C:13]([N:35]([CH:22]([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[C:23]2[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=2)[CH2:36][CH2:37][CH2:38][CH2:39][C:40]([OH:42])=[O:41])=[O:15])=[O:7])=[CH:20][CH:21]=1

Participants

5

Reactant 3

HCID 14797Potassium HydroxideHCID 20292147HCID 20292147, compoundHCID 20292190HCID 20292190, compound

Product 1

HCID 20292224HCID 20292224, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Analogously to Example 1, by using equivalent quantities, reacting N-(p-chlorobenzoyl)-5-(n-butylamino)valeric acid and ethyl 5-benzhydrylaminovalerate and suitable processing, dissolving the evaporation residue in ethanol, adding an ethanolic solution of potassium hydroxide, stirring for 12 hours at room temperature and further processing yields N-[N-(p-chlorobenzoyl)-5-(n-butylamino)pentanoyl]-5-benzhydrylaminovaleric acid.

Sources & evidence

ORD record
ord-f4f153c8d1c143ab81238b09f56d0a20
Source dataset
uspto-grants-1981_02
Patent number
US04250183

Reaction notes

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