Potassium Hydroxide → HCID 22814616, compound

HRID 1413633Notes

Reaction equation

HRID 1413633 reaction equation
[Cl:1][C:2]1[CH:18]=[CH:17][C:5]([C:6]([NH:8][C@H:9]([C:14]([OH:16])=O)[CH2:10][CH2:11][S:12][CH3:13])=[O:7])=[CH:4][CH:3]=1.[CH2:19]([NH:26][CH2:27][CH2:28][CH2:29][C:30]([O:32]CC)=[O:31])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1.[OH-].[K+]>C(O)C>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]([NH:8][C@H:9]([C:14]([N:26]([CH2:19][C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=2)[CH2:27][CH2:28][CH2:29][C:30]([OH:32])=[O:31])=[O:16])[CH2:10][CH2:11][S:12][CH3:13])=[O:7])=[CH:17][CH:18]=1

Participants

5

Reactant 3

HCID 14797Potassium HydroxideHCID 2357272HCID 2357272, compoundHCID 12220642HCID 12220642, compound

Product 1

HCID 22814616HCID 22814616, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Analogously to Example 1, by using equivalent quantities, reacting N-(p-chlorobenzoyl)-L-methionine and ethyl 4-benzylaminobutyrate and suitable processing, dissolving the evaporation residue in ethanol, adding an ethanolic solution of potassium hydroxide, stirring for 12 hours at room temperature and further processing yields N-[N-(p-chlorobenzoyl)-L-methionyl]-4-benzylaminobutyric acid.

Sources & evidence

ORD record
ord-a041f5c2d08c45cd852aa3cf16212b00
Source dataset
uspto-grants-1981_02
Patent number
US04250183

Reaction notes

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