HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Chlorophenol → 2-(3-Chlorophenoxy)nicotinic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Chlorophenol | HCID 7933 | — |
| Reactant | 2-Chloronicotinic acid | HCID 76258 | — |
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-(3-Chlorophenoxy)nicotinic acid | HCID 12202641 | 88.6% |
Reaction Steps
In the same manner as in Example 1(a), 15.8 grams (0.1 mole) 2-chloronicotinic acid, 64.0 grams (0.5 mole) 3-chlorophenol, 45 grams (0.21 mole) 25% sodium methoxide solution and 100 milliliters methanol were combined to produce 22.1 grams (88.6% of theoretical yield) of 2-(3-chlorophenoxy) nicotinic acid, m.p. 161°-164° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04251263 |
| Source dataset | uspto-grants-1981_02 |
| ORD ID | ord-a9a53cb06af14ca8bf57205d98505995 |
| Source note | uspto-grants-1981_02 |