Isopropylamine → N-Isopropyl-3,4-dimethyl-2,6-dinitroaniline

HRID 1413664Notes

Reaction equation

HRID 1413664 reaction equation
Cl[C:2]1[C:3]([N+:13]([O-:15])=[O:14])=[C:4]([CH3:12])[C:5]([CH3:11])=[CH:6][C:7]=1[N+:8]([O-:10])=[O:9].[CH:16]([NH2:19])([CH3:18])[CH3:17]>>[CH:16]([NH:19][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][C:5]([CH3:11])=[C:4]([CH3:12])[C:3]=1[N+:13]([O-:15])=[O:14])([CH3:18])[CH3:17]

Participants

3

Reactant 2

HCID 6363IsopropylamineHCID 134551024-Chloro-3,5-dinitro-o-xylene

Product 1

HCID 12767671N-Isopropyl-3,4-dimethyl-2,6-dinitroanilineYield 80%

Procedure

4-Chloro-3,5-dinitro-o-xylene (10.0 grams, 0.043 mole) and i-propylamine (10.1 grams, 0.17 mole) are mixed and refluxed for 12 hours using an efficient reflux condenser. The mixture is then cooled and poured into 100 ml. of 5% hydrochloric acid and extracted with diethyl ether. The ether extract is dried over magnesium sulfate. Removal of the drying agent and solvent leaves an orange oil which readily solidifies. The product is recrystallized from methanol to give 8.7 grams (80%) of an orange solid with melting point 69° C. to 70° C.

Workup

  1. temperaturerefluxed for 12 hours
  2. temperatureThe mixture is then cooled
  3. additionpoured into 100 ml
  4. extractionof 5% hydrochloric acid and extracted with diethyl ether
  5. extractionThe ether extract
  6. dry with materialis dried over magnesium sulfate
  7. customRemoval of the drying agent and solvent
  8. customleaves an orange oil which
  9. customThe product is recrystallized from methanol

Sources & evidence

ORD record
ord-88beca4c139f4c6095dd96f11dc6bb38
Source dataset
uspto-grants-1981_02
Patent number
US04251264

Reaction notes

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