反应详情

A mixture of 4-chloro-α-methoxy-5-nitro-o-toluic acid (3.6 g.) and phosphorus pentachloride (3.0 g.) in 120 ml of benzene is refluxed for thirty minutes. The mixture is then concentrated in vacuo and the residue boiled with 200 ml of hexane and filtered hot. The filtrate is partially concentrated and chilled to give 2.5 g. of white solid with mp 63°-65°.

1. temperatureis refluxed for thirty minutes
2. concentrationThe mixture is then concentrated in vacuo
3. filtrationfiltered hot
4. concentrationThe filtrate is partially concentrated
5. temperaturechilled
6. customto give 2.5 g