Methyl formate → HCID 19845137, compound

HRID 1413701Notes

Reaction equation

HRID 1413701 reaction equation
[OH:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][N+:8]#[C-:9].NCCCCCC[OH:17].C(OC)=O>>[OH:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][NH:8][CH:9]=[O:17]

Participants

4

Reactant 3

HCID 7865Methyl formateHCID 199606-Amino-1-hexanolHCID 20290322HCID 20290322, compound

Product 1

HCID 19845137HCID 19845137, compound

Procedure

The 6-hydroxyhexyl isocyanide used in the preparation of the isocyano copolymer was synthesized as follows: To 214.4 g (2 moles) of 6-aminohexyl alcohol, which was stirred and heated to keep the material molten, was added dropwise 120.1 g (2 moles) of methyl formate. When the addition was completed, the mixture was stirred and heated at reflux for two hours. After removal of the methanol formed in vacuo, the residue was recrystallized from tetrahydrofuran to give 237.4 g of 6-hydroxyhexylformamide, m.p. 43.5°-45°.

Workup

  1. customwas synthesized
  2. temperatureheated
  3. additionWhen the addition
  4. temperatureheated
  5. temperatureat reflux for two hours
  6. customAfter removal of the methanol
  7. customformed in vacuo
  8. customthe residue was recrystallized from tetrahydrofuran

Sources & evidence

ORD record
ord-41b690abfdd9447cac729889a2353f93
Source dataset
uspto-grants-1981_02
Patent number
US04251421

Reaction notes

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