1-Methyl-3-(2-methylpropyl)-4-(phenylmethyl)piperazinone → 3-Isobutyl-1-methyl-piperazin-2-one

HRID 1413723Notes

Reaction equation

HRID 1413723 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][N:5](CC2C=CC=CC=2)[CH:4]([CH2:15][CH:16]([CH3:18])[CH3:17])[C:3]1=[O:19].[H][H]>CO.[Pd]>[CH3:1][N:2]1[CH2:7][CH2:6][NH:5][CH:4]([CH2:15][CH:16]([CH3:17])[CH3:18])[C:3]1=[O:19]

Participants

5

Reactant 2

HCID 233196871-Methyl-3-(2-methylpropyl)-4-(phenylmethyl)piperazinoneHCID 178418361HCID 178418361, compound2×

Product 1

HCID 233196533-Isobutyl-1-methyl-piperazin-2-one

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

1-Methyl-3-(2-methylpropyl)-4-(phenylmethyl)piperazinone (Example 47, 2.1 g.) is dissolved in methanol (200 ml.), 10% palladium charcoal (1.0 g.) is added and the product is hydrogenated (50 lb. initial hydrogen pressure until the uptake of hydrogen ceased. The solution is filtered and the methanol is removed under reduced pressure to give the title compound as an oil.

Workup

  1. filtrationThe solution is filtered
  2. customthe methanol is removed under reduced pressure

Sources & evidence

ORD record
ord-f11c50b85ba644ecbcb3a913caca8fd1
Source dataset
uspto-grants-1981_02
Patent number
US04251438

Reaction notes

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