3-Methyl-3-(2-methylpropyl)-1,4-bis(phenylmethyl)piperazinone → 3-Methyl-3-(2-methylpropyl)-4-(phenylmethyl)-piperazinone

HRID 1413724Notes

Reaction equation

HRID 1413724 reaction equation
[CH3:1][C:2]1([CH2:23][CH:24]([CH3:26])[CH3:25])[N:7]([CH2:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH2:6][CH2:5][N:4](CC2C=CC=CC=2)[C:3]1=[O:22].C(OC(N1CCN(CC2C=CC=CC=2)C(=O)C1CCSC)=O)(C)(C)C>>[CH3:1][C:2]1([CH2:23][CH:24]([CH3:26])[CH3:25])[N:7]([CH2:8][C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=2)[CH2:6][CH2:5][NH:4][C:3]1=[O:22]

Participants

3

Reactant 2

HCID 135204123-Methyl-3-(2-methylpropyl)-1,4-bis(phenylmethyl)piperazinoneHCID 233196654-t-Butoxycarbonyl-3-[2-(methylthio)ethyl)-1-(phenylmethyl)piperazinone

Product 1

HCID 135204133-Methyl-3-(2-methylpropyl)-4-(phenylmethyl)-piperazinone

Procedure

Following the general procedure of Example 43 and making non-critical variations, but sustituting 3-methyl-3-(2-methylpropyl)-1,4-bis(phenylmethyl)piperazinone (XXI, Example 51) for 4-t-butoxycarbonyl-3-[2-(methylthio)ethyl]-1-(phenylmethyl)piperazinone there is obtained the title compound, m.p. 158°-161°.

Sources & evidence

ORD record
ord-40d04cad47374d108b9dc638dfc83a6e
Source dataset
uspto-grants-1981_02
Patent number
US04251438

Reaction notes

Loading…