Dimethyl Sulfone → HCID 86737500, compound

Participants

Reaction Steps

A suspension of 2.4 g. of sodium hydride (50% suspension in oil) and 7.05 g. of dimethylsulfone in 17.5 ml. of dimethylsulfoxide was stirred with the exclusion of moisture for 2 hours at 50° C. 6.9 G. of methyl 4-tert. butyl-3,5-bis(dimethylamino)benzoate were then added, and the mixture was stirred at room temperature for 1.5 hours. The solution was diluted with 150 ml. of ice water, the precipitated solid material filtered off, washed with water and recrystallized from methanol, there being obtained 4'-tert. butyl-3',5'-bis(dimethylamino)-2-methylsulfonylacetophenone having a melting point of 177°-179° C.

Provenance & Evidence