HCID 20290428, compound → HCID 20290418, compound

HRID 1413753Notes

Reaction equation

HRID 1413753 reaction equation
[CH3:1][N:2]([C:6]1[C:15]([N+:16]([O-])=O)=[CH:14][C:9]([C:10]([O:12][CH3:13])=[O:11])=[CH:8][C:7]=1[N+:19]([O-])=O)[C:3](=[O:5])[CH3:4]>[Pd].CO>[NH2:19][C:7]1[CH:8]=[C:9]([CH:14]=[C:15]([NH2:16])[C:6]=1[N:2]([CH3:1])[C:3](=[O:5])[CH3:4])[C:10]([O:12][CH3:13])=[O:11]

Participants

4

Reactant 1

HCID 20290428HCID 20290428, compound

Product 1

HCID 20290418HCID 20290418, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

9.7 G. of methyl 4-(N-methylacetamido)-3,5-dinitrobenzoate in 100 ml. of methanol were hydrogenated under normal pressure and at room temperature in the presence of 1 g. of palladium/carbon. After uptake of the theoretical amount of hydrogen, the solution was filtered off from the catalyst and evaporated. the residue was recrystallized from methanol, there being obtained methyl 3,5-diamino-4-(N-methylacetamido)-benzoate having a melting point of 221°-222° C.

Workup

  1. customwere hydrogenated under normal pressure and at room temperature in the presence of 1 g
  2. filtrationAfter uptake of the theoretical amount of hydrogen, the solution was filtered off from the catalyst
  3. customevaporated
  4. customthe residue was recrystallized from methanol, there

Sources & evidence

ORD record
ord-e7b0c60bbdb146d1a8353baccee57702
Source dataset
uspto-grants-1981_02
Patent number
US04251454

Reaction notes

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