Benzoyl chloride → HCID 20290837, compound

Participants

Reaction Steps

To a suspension of 2,3-dihydro-7-methyl-9-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-5H-pyrido[1,2,3-de]-1,4-benzoxazin-5-one in pyridine is added benzoyl chloride. The suspension is stirred and heated at reflux until homogenous. The solution is added to ice cold 2 N hydrochloric acid. The resultant mixture is extracted with ether; the etheral solution is dried with anhydrous magnesium sulfate, filtered and evaporated at reduced pressure to give 2,3-dihydro-7-methyl-9-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)-ethyl]-5H-pyrido[1,2,3-de]-1,4-benzoxazin-5-one benzoate.

Provenance & Evidence