Water → HCID 20290822, compound

Participants

Reaction Steps

To a solution of 8-methoxy-4-methyl-6-[2,2,2-trifluoro-1-benzyloxy-1-(trifluoromethyl)ethyl]-2(1H)-quinolinone in dimethylformamide is added potassium carbonate and methyl iodide. The solution is stirred and heated until analysis by thin layer chromatography indicates the reaction is complete. The solution is cooled and added to water. The aqueous mixture is extracted with ether. The etheral solution is dried with anhydrous magnesium sulfate, filtered and evaporated at reduced pressure. The residual material is purified by chromatography on silicic acid to give 8-methoxy-1,4-dimethyl-6-[2,2,2-trifluoro-1-benzyloxy-1-(trifluoromethyl)ethyl]-2(1H)-quinolinone.

Provenance & Evidence