Sodium borohydride → HCID 13223064, compound

Participants

Reaction Steps

6-Acetyl-3,4-dihydro-2,2-dimethyl-trans-4-piperidino-2H-benzo[b]pyran-3-ol (1.00 g) was dissolved in methanol (10 ml) and water (2 ml) and treated with sodium borohydride (0.10 g) with stirring at room temperature during 5 minutes. After an additional 2 hours stirring, the reaction mixture was diluted with water (100 ml). Extraction using diethyl ether gave 1-hydroxy-1-[trans-2,2-dimethyl-3-hydroxy-4-piperidinochroman-6-yl]-ethane (1.00 g) which was dissolved in dry ether and treated with ethereal hydrogen chloride giving the hydrochloride salt (0.90 g) m.p. 179°-181° C. as a white powder from ethanol-ether.

Provenance & Evidence