反应详情

A mixture of 16.4 g of 2-(p-prenylphenyl)propionitrile, 60 g of sodium hydroxide, 100 ml of water and 120 ml of methanol was stirred at 70°-75° C. for 8 hours. The resulting solution was concentrated and acidified with dilute hydrochloric acid, followed by extraction with ethyl ether and washing with water. The ethereal solution was extracted with 5% aqueous potassium hydroxide solution. The aqueous layer was acidified with dilute hydrochloric acid, and extracted with ether, which was then washed with water, dried over anhydrous magnesium sulfate and decolorized with activated charcoal. The ether was removed to give 15.5 g of 2-(p-prenylphenyl)propionic acid. ##STR1##

1. concentrationThe resulting solution was concentrated
2. extractionfollowed by extraction with ethyl ether
3. washwashing with water
4. extractionThe ethereal solution was extracted with 5% aqueous potassium hydroxide solution
5. extractionextracted with ether, which
6. washwas then washed with water
7. dry with materialdried over anhydrous magnesium sulfate
8. customThe ether was removed