Cyclopropylamine → 3-tert.-Butyl-5-[2-(2-hydroxy-3-cyclopropylaminopropoxy)-styryl]-isoxazole
Reaction equation
[C:1]([C:5]1[CH:9]=[C:8]([CH:10]=[CH:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[O:18][CH2:19][CH:20]2[O:22][CH2:21]2)[O:7][N:6]=1)([CH3:4])([CH3:3])[CH3:2].[CH:23]1([NH2:26])[CH2:25][CH2:24]1>>[C:1]([C:5]1[CH:9]=[C:8]([CH:10]=[CH:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[O:18][CH2:19][CH:20]([OH:22])[CH2:21][NH:26][CH:23]2[CH2:25][CH2:24]2)[O:7][N:6]=1)([CH3:2])([CH3:3])[CH3:4]Participants
3
Procedure
7 g (0.023 mole) of 3-tert.-butyl-5-[2-(2,3-epoxypropoxy)-styryl]-isoxazole and 2.7 g (0.047 mole) of cyclopropylamine are reacted by the method described in Example 1. 5.8 g of an oil are obtained; this is dissolved in diethyl ether and precipitated with 2 g of oxalic acid dissolved in a small amount of ethanol. 2.7 g (26% of theory) of colorless crystals are obtained. Melting point 170°-174° C.
Sources & evidence
- ORD record
- ord-a572d62e95734157a25c8bdf383bece4
- Source dataset
- uspto-grants-1981_02
- Patent number
- US04251539
Reaction notes
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