Acetic Acid → HCID 20291103, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 4-chlorophenol (51.2 g), trifluoroacetaldehyde methyl hemiacetal (26 g) and acetic acid (16 ml) was stirred at a temperature of 14° C. and concentrated sulfuric acid (60 ml) was added slowly and the temperature of the mixture was kept below 25° C. The mixture was then stirred for a period of 2 hours at a temperature of 40° C. and the mixture poured into water. The product was recrystallised from cyclohexane/diethyl ether to give 1,1-bis(5-chloro-2-hydroxyphenyl)-2,2,2-trifluoroethane (25 g), m.p. 144° C.

Provenance & Evidence