反应详情

Boron tribromide (1 ml) in dichloromethane (10 ml) was added dropwise to a solution of 2-(5-fluoro-2-hydroxyphenyl)-2-(5-fluoro-2-methoxyphenyl)propane (0.5 g) in dichloromethane (10 ml) at -70° C. The solution was stirred at this temperature for one hour and water was then added. The organic layer was separated, dried (Na2SO4) and the solvent removed to give a colourless product which crystallised from hexane to give colourless prisms of 2,2'-isopropylidene bis(4-fluorophenol) (0.375 g); m.p. 155° C.

1. customThe organic layer was separated
2. dry with materialdried (Na2SO4)
3. customthe solvent removed
4. customto give a colourless product which
5. customcrystallised from hexane