Hydrochloric Acid → HCID 53898321, compound

Participants

Reaction Conditions

Reaction Steps

Sodium borohydride (3.5 g) was added portionwise to a stirred solution of bis(5-chloro-2-hydroxy-3-nitrophenyl) ketone (10 g) in ethanol (150 ml) the solution being maintained at a temperature of 0° C. On completion of the addition the temperature of the solution was allowed to rise to ambient temperature and the mixture was stirred overnight at ambient temperature. The solution was diluted with water, acidified with hydrochloric acid and the product extracted into ethyl acetate. The solvent was removed by distillation under reduced pressure to give bis-(5-chloro-2-hydroxy-3-nitrophenyl)methyl alcohol (9.0 g) which on recrystallisation from ethanol/hexane had a melting point of 180° C.

Provenance & Evidence