Isobutanol → HCID 20291094, compound

Participants

Reaction Steps

A mixture of bis(5-chloro-2-hydroxy-3-nitrophenyl)methyl chloride (5 g) and isobutanol (50 ml) was stirred at a temperature of 0° C. and sodium hydride (1 g) was added portionwise. On completion of the addition the mixture was stirred for a further hour and poured into water. The aqueous solution was extracted into ether/petroleum ether and the solvents removed by distillation under reduced pressure. The residue was recrystallised from petroleum ether (b.p. 40°-60° C.) to give 4.3 g of bis(5-chloro-2-hydroxy-3-nitrophenyl)methyl isobutyl ether m.p. 95° C.

Provenance & Evidence