Ethylene Oxide → 2-((3-(Dimethylamino)propyl)amino)ethanol

HRID 1413926Notes

Reaction equation

[CH3:1][N:2]([CH3:7])[CH2:3][CH2:4][CH2:5][NH2:6].[CH2:8]1[O:10][CH2:9]1>>[CH3:1][N:2]([CH3:7])[CH2:3][CH2:4][CH2:5][NH:6][CH2:8][CH2:9][OH:10]

Participants

Reactant 2

HCID 6354Ethylene Oxide

HCID 7993N,N-Dimethyl-1,3-propanediamine

Product 1

HCID 1044702-((3-(Dimethylamino)propyl)amino)ethanol

Conditions

Temperature: 115 °C

Procedure

To a one liter stirred autoclave was charged 500 g 3-dimethylaminopropyl amine. A nitrogen atmosphere was provided and the sealed autoclave was heated to 115°C. Ethylene oxide (140 g) was added incrementally over 3 hours. Heating was continued for 15 minutes.

Workup

customA nitrogen atmosphere was provided
temperatureHeating

Sources & evidence

ORD record: ord-12b10b13ddea430b849ef9a44ee62374
Source dataset: uspto-grants-1981_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04251637

Reaction notes

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