Sulfuric Acid → HCID 12562796, compound

HRID 1413928Notes

Reaction equation

HRID 1413928 reaction equation
[Cl:1][C:2]1[N:3]=[N:4][C:5]([N:8]2[C:12]([NH2:13])=[C:11]([C:14]#[N:15])[CH:10]=[N:9]2)=[CH:6][CH:7]=1.S(=O)(=O)(O)[OH:17]>>[Cl:1][C:2]1[N:3]=[N:4][C:5]([N:8]2[C:12]([NH2:13])=[C:11]([C:14](=[O:17])[NH2:15])[CH:10]=[N:9]2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 1118Sulfuric AcidHCID 6401133HCID 6401133, compound

Product 1

HCID 12562796HCID 12562796, compound

Procedure

A mixture of 3 g. of 3-chloro-6-(4-cyano-5-amino-1-pyrazolyl)-pyridazine (prepared according to Example 24) and 10.5 ml. of concentrated sulphuric acid is stirred at room temperature for one hour. Then the mixture is poured onto ice, the precipitate filtered, washed with water and triturated with 15 ml. of hot ethanol, filtered and dried. Yield: 3.05 g. (93.5%); m.p.: 314°-317° C.

Workup

  1. additionA mixture of 3 g
  2. additionThen the mixture is poured onto ice
  3. filtrationthe precipitate filtered
  4. washwashed with water
  5. customtriturated with 15 ml
  6. filtrationof hot ethanol, filtered
  7. customdried

Sources & evidence

ORD record
ord-dc99a3182f41456c85b997894c2233ed
Source dataset
uspto-grants-1981_02
Patent number
US04251658

Reaction notes

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