Acetic Anhydride → HCID 54284781, compound

HRID 1413932Notes

Reaction equation

HRID 1413932 reaction equation
[O:1]([C:8]1[N+:13]([O-])=[CH:12][CH:11]=[C:10]([CH2:15][OH:16])[CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:17](OC(=O)C)(=[O:19])[CH3:18]>O1CCOCC1>[C:17]([O:16][CH2:15][C:10]1[CH:9]=[C:8]([O:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)[N:13]=[CH:12][CH:11]=1)(=[O:19])[CH3:18]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 20291302HCID 20291302, compound

Product 1

HCID 54284781HCID 54284781, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

In accordance with the process of Example 1, 37 g of 6-phenoxy-4-picoline was oxidized by using hydrogen peroxide-glacial acetic acid to obtain 28.2 g of 6-phenoxypyridine-4-methanol-N-oxide. Then, 28.2 g of 6-phenoxypyridine-4-methanol-N-oxide and 28.6 g of acetic anhydride were added to 400 ml of dioxane and the mixture was refluxed for 5 hours to react them.

Workup

  1. temperaturethe mixture was refluxed for 5 hours
  2. customto react them

Sources & evidence

ORD record
ord-ee44244e68674f3aa90d1c26a23a75e9
Source dataset
uspto-grants-1981_02
Patent number
US04251662

Reaction notes

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