Ammonium Chloride → HCID 20291231, compound

Participants

Reaction Steps

A solution of 0.05 mole of 4-methylphenyl magnesium bromide in 500 ml of anhydrous ether was treated with 4-benzoylpyridine in 500 ml anhydrous ether. After stirring the resulting mixture for 1.5 hours at 25° , an aqueous solution of ammonium chloride was added causing a solid to form which was filtered. Recrystallization of this material from 95% ethanol afforded the desired α-(4-methylphenyl)-α-phenyl-4-pyridine methanol, m.p. 192°-195° C. The corresponding 4-chlorophenyl (m.p. 198°-202° C.) and 4-methoxyphenyl (m.p. 204°-206° C.) derivatives were also prepared by the same method, using equivalent amounts of the appropriate starting materials.

Provenance & Evidence