2-{[2-Chloro-4-(trifluoromethyl)phenyl]amino}-3-methylbutanoic acid → HCID 20289291, compound

HRID 1413973Notes

Reaction equation

HRID 1413973 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[CH:4][C:3]=1[NH:12][CH:13]([CH:17]([CH3:19])[CH3:18])[C:14]([OH:16])=[O:15].[F:20][C:21]1[CH:34]=[CH:33][C:24]([CH2:25][C:26]2[CH:30]=[CH:29][NH:28][C:27]=2[CH2:31]O)=[CH:23][CH:22]=1>CCOCC>[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[CH:4][C:3]=1[NH:12][CH:13]([CH:17]([CH3:19])[CH3:18])[C:14]([O:16][CH2:31][C:27]1[NH:28][CH:29]=[CH:30][C:26]=1[CH2:25][C:24]1[CH:23]=[CH:22][C:21]([F:20])=[CH:34][CH:33]=1)=[O:15]

Participants

4

Reactant 2

HCID 39476432-{[2-Chloro-4-(trifluoromethyl)phenyl]amino}-3-methylbutanoic acidHCID 544646223-(4-Fluorobenzyl)-pyrrolylmethyl alcohol

Product 1

HCID 20289291HCID 20289291, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

The acid chloride of 2-(2-chloro-4-trifluoromethylphenylamino)-3-methylbutanoic acid is reacted with 3-(4-fluorobenzyl)-pyrrolylmethyl alcohol in ether as in Example 1 to give 3-(4-fluorobenzyl)-pyrrolylmethyl 2-(2-chloro-4-trifluoromethylphenylamino)-3-methylbutanoate.

Sources & evidence

ORD record
ord-887ec229da3842f9b8899c3473ab22dc
Source dataset
uspto-grants-1981_02
Patent number
US04252724

Reaction notes

Loading…