2-(2-Fluoro-4-trifluoromethylphenylamino)-3-methylbutanoic acid → HCID 20289284, compound

HRID 1413975Notes

Reaction equation

HRID 1413975 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:14]=[CH:15][CH:16]=1)[CH2:6][C:7]1[CH:11]=[CH:10][NH:9][C:8]=1[CH2:12][OH:13].[Cl:17][C:18]1[CH:19]=[C:20]([CH:29]=[CH:30][CH:31]=1)[CH2:21][C:22]1[CH:26]=[CH:25][NH:24][C:23]=1[CH2:27][OH:28].[F:32][C:33]1[CH:38]=[C:37]([C:39]([F:42])([F:41])[F:40])[CH:36]=[CH:35][C:34]=1[NH:43][CH:44]([CH:48]([CH3:50])[CH3:49])[C:45](O)=[O:46]>>[F:32][C:33]1[CH:38]=[C:37]([C:39]([F:42])([F:41])[F:40])[CH:36]=[CH:35][C:34]=1[NH:43][CH:44]([CH:48]([CH3:50])[CH3:49])[C:45]([O:13][CH2:12][C:8]1[NH:9][CH:10]=[CH:11][C:7]=1[CH2:6][C:5]1[CH:14]=[CH:15][CH:16]=[C:3]([O:2][CH3:1])[CH:4]=1)=[O:46].[F:32][C:33]1[CH:38]=[C:37]([C:39]([F:42])([F:41])[F:40])[CH:36]=[CH:35][C:34]=1[NH:43][CH:44]([CH:48]([CH3:50])[CH3:49])[C:45]([O:28][CH2:27][C:23]1[NH:24][CH:25]=[CH:26][C:22]=1[CH2:21][C:20]1[CH:29]=[CH:30][CH:31]=[C:18]([Cl:17])[CH:19]=1)=[O:46]

Participants

5

Reactant 3

HCID 202839832-(2-Fluoro-4-trifluoromethylphenylamino)-3-methylbutanoic acidHCID 53934895HCID 53934895, compoundHCID 54485745HCID 54485745, compound

Product 2

HCID 20289284HCID 20289284, compoundHCID 20289298HCID 20289298, compound

Procedure

Each of the alcohols, 3-(3-methoxybenzyl)-pyrrolylmethyl alcohol and 3-(3-chlorobenzyl)-pyrrolylmethyl alcohol, is reacted with 2-(2-fluoro-4-trifluoromethylphenylamino)-3-methylbutanoic acid using the procedure of Example 3 to yield 3-(3-methoxybenzyl)-pyrrolylmethyl 2-(2-fluoro-4-trifluoromethylphenylamino)-3-methylbutanoate and 3-(3-chlorobenzyl)pyrrolylmethyl 2-(2-fluoro-4-trifluoromethylphenylamino)-3-methylbutanoate.

Sources & evidence

ORD record
ord-ad2334879f3d4dbc8d816030cfae06b3
Source dataset
uspto-grants-1981_02
Patent number
US04252724

Reaction notes

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