3,4,5-Trimethoxyaniline → HCID 3051889, compound

HRID 1414001Notes

Reaction equation

HRID 1414001 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:8](Cl)=[O:9])[CH2:4][CH2:3]1.[CH3:11][O:12][C:13]1[CH:14]=[C:15]([CH:17]=[C:18]([O:22][CH3:23])[C:19]=1[O:20][CH3:21])[NH2:16]>C(Cl)Cl>[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:8](=[O:9])[NH:16][C:15]2[CH:17]=[C:18]([O:22][CH3:23])[C:19]([O:20][CH3:21])=[C:13]([O:12][CH3:11])[CH:14]=2)[CH2:4][CH2:3]1

Participants

4

Reactant 2

HCID 322853,4,5-TrimethoxyanilineHCID 30169354-Methyl-1-piperazinecarbonyl chloride

Product 1

HCID 3051889HCID 3051889, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

A solution of 10 g (0.061 mole) 1-methyl-4-chloroformyl-piperazine in 100 ml dry methylene chloride is added to a solution of 11.2 g (0.061 mole) 3,4,5-trimethoxy-aniline in a 100 ml methylenechloride. After stirring at ambient temperature for 24 hours, the solvent is evaporated off in vacuo; the residue is dissolved in the minimum of ethanol and then the crude hydrochloride precipated by the addition of diethyl ether, and dried.

Workup

  1. customthe solvent is evaporated off in vacuo
  2. dissolutionthe residue is dissolved in the minimum of ethanol
  3. additionthe crude hydrochloride precipated by the addition of diethyl ether
  4. customdried

Sources & evidence

ORD record
ord-2268128d4723465f93d91335554159f6
Source dataset
uspto-grants-1981_02
Patent number
US04252804

Reaction notes

Loading…