Ammonia → HCID 20289480, compound

Participants

Reaction Conditions

Reaction Steps

Ammonia (0.88, 0.2 ml) was added to a solution of 3-[2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl) ethyl]-1H-indole-5-carboxylic acid, 4-nitrophenyl ester (0.3 g) in warm (50° C.) dimethylformamide (3 ml). The mixture was stirred at 50° C. for 4 hours., poured into water (40 ml) and stirred for a further 0.5 hours. The precipitate (0.21 g) was collected and crystallised from ethanol to give the title compound (0.12 g) as an off-white solid m.p. 254°-6° C. T.L.C. Silica, Ethyl acetate:2-propanol:water:ammonia (25:15:8:2) Rf 0.75.

Provenance & Evidence