HCID 20289481, compound → Maleate(2-)

HRID 1414029Notes

Reaction equation

HRID 1414029 reaction equation
[NH2:1][CH2:2][CH2:3][C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([C:13]([NH:15][CH:16]([CH3:18])[CH3:17])=[O:14])[CH:11]=2)[NH:6][CH:5]=1.C[OH:20].[C:21]([O:24][CH2:25][CH3:26])(=[O:23])[CH3:22]>>[CH3:17][CH:16]([NH:15][C:13]([C:10]1[CH:11]=[C:12]2[C:7](=[CH:8][CH:9]=1)[NH:6][CH:5]=[C:4]2[CH2:3][CH2:2][NH:1][C:21](=[O:23])[O:24][CH2:25][C:26]1[CH:11]=[CH:12][CH:4]=[CH:3][CH:2]=1)=[O:14])[CH3:18].[C:13]([O-:14])(=[O:20])/[CH:10]=[CH:22]\[C:21]([O-:24])=[O:23]

Participants

4

Reactant 2

HCID 20289481HCID 20289481, compoundHCID 21584119Ethylacetate methanol

Product 2

HCID 5288227Maleate(2-)HCID 131712085HCID 131712085, compound

Procedure

(ii)b [2-[5-[[(1-Methylethyl)amino]carbonyl]1H-indol-3-yl]ethyl carbamic acid, phenylmethyl ester (0.4 g) gave 3-(2-aminoethyl)-N-(1-methylethyl)-1H-indole-5-carboxamide, maleate (0.25 g) as a white crystalline solid m.p. 174°-5° C. (from methanol/ethyl acetate)

Sources & evidence

ORD record
ord-313df3519e6f4f53be471d943f021dd2
Source dataset
uspto-grants-1981_02
Patent number
US04252803

Reaction notes

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