Butyl bromide → HCID 86737514, compound

Participants

Reaction Steps

Following the method of Example 16(i), [2-[5-(aminocarbonyl)-1H-indol-3-yl]ethyl]carbamic acid, phenylmethyl ester (1.5 g), sodium hydride (0.16 g) and 1-bromobutane (1 ml) gave a pale brown oily solid (1.5 g). Chromatography on a silica column (Kieselgel 60, 60 g) eluted with chloroform containing 1% methanol gave the title compound (1.0 g) as a colourless crystalline solid m.p. 138°-9° (ethyl acetate).

Provenance & Evidence