Beta-Alanine → HCID 131712089, compound

Participants

Reaction Steps

A mixture of 9.7 g. (52 mmole) 2-(2-hydroxyethylamino)-4-chloroaniline, 6.9 g. (78 mmole) β-alanine, 46 ml. concentrated hydrochloric acid and 54 ml. of water is heated at reflux with stirring for 24 hrs. After cooling, the solution is concentrated, and made basic with 10% aqueous sodium hydroxide. Continuous liquid-liquid extraction of the aqueous solution with ethyl acetate affords 9.9 g. of the product, which is converted to it hydrochloride salt. The product has a m.p. of 196°-200° C. after recrystallization from methanol/ethyl acetate.

Provenance & Evidence