Ammonium Chloride → HCID 12875799, compound

HRID 1414056Notes

Reaction equation

HRID 1414056 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][S:8][CH2:9][CH2:10][C:11](=[NH:15])OCC.[Cl-:16].[NH4+:17]>CO>[ClH:16].[ClH:16].[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][S:8][CH2:9][CH2:10][C:11]([NH2:15])=[NH:17]

Participants

4

Reactant 2

HCID 25517Ammonium ChlorideHCID 12853022HCID 12853022, compound

Product 1

HCID 12875799HCID 12875799, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Ethyl 3-(2-pyridylmethylthio)propionimidate was reacted with an equimolar amount of ammonium chloride in methanol for 2 hours at room temperature and the product was recrystallized from a mixture of ethanol and ether to provide 3-(2-pyridylmethylthio)propionamidine dihydrochloride showing a melting point of 140°-143° C.

Workup

  1. customthe product was recrystallized from a mixture of ethanol and ether

Sources & evidence

ORD record
ord-5a6cacc825614e5987451656ea9b1211
Source dataset
uspto-grants-1981_02
Patent number
US04252819

Reaction notes

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