Potassium Hydroxide → 55837-20-2

HRID 1414067Notes

Reaction equation

[OH-].[K+].Br.[Br:4][C:5]1[CH:14]=[C:13]2[C:8]([C:9](=[O:26])[N:10]([CH2:15][C:16]([CH2:18][CH:19]3[CH:24]([OH:25])[CH2:23][CH2:22][CH2:21][NH:20]3)=[O:17])[CH:11]=[N:12]2)=[CH:7][C:6]=1[Cl:27]>CO>[Br:4][C:5]1[CH:14]=[C:13]2[C:8]([C:9](=[O:26])[N:10]([CH2:15][C:16]([CH2:18][CH:19]3[CH:24]([OH:25])[CH2:23][CH2:22][CH2:21][NH:20]3)=[O:17])[CH:11]=[N:12]2)=[CH:7][C:6]=1[Cl:27]

Participants

Conditions

Temperature: 20 °C

Procedure

A methanolic potassium hydroxide solution (10 g of KOH/100 ml) was added to a suspension of the product of Step E in methanol and the mixture was stirred for 30 minutes at 20° C. The product was washed with methanol, then with water and was dried to obtain dextrorotary 7-bromo-6-chloro-3-[3-(3-hydroxy-2-piperidyl)-acetonyl]-4(3H)-quinazolinone melting at 205° C. and having a specific rotation of [α]D20 =+7.5° (c=1% in dimethylformamide).

Workup

washThe product was washed with methanol
dry with materialwith water and was dried

Sources & evidence

ORD record: ord-d9bd458cb1b646bebda8099b54d2a1e9
Source dataset: uspto-grants-1981_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04252947

Reaction notes

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